Therapeutic Approach of Primary Bone Tumours by Bisphosphonates

Author(s): G. Moriceau, B. Ory, B. Gobin, F. Verrecchia, F. Gouin, F. Blanchard, F. Redini, D. Heymann.

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 27 , 2010

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Abstract:

Bone tumours can be dissociated in two main categories: i) primary bone tumours (benign or malignant) including mainly osteosarcoma and other sarcomas. ii) and giant cell tumour and bone metastases originate from others cancer (Breast, prostate, kidney cancer, etc). These tumours are able to destroy or/and induce a new calcified matrix. However, the first step of bone tumour development is associated with an induction of bone resorption and the establishment of a vicious cycle between the osteoclasts and the tumour growth. Indeed, bone resorption contributes to the pathogenesis of bone tumour by the release of cytokines (IL6, TNFα) which govern the bone tumours development and which are trapped into the bone matrix. Bisphosphonates (BPs) are chemical compounds of P-C-P structure with a high affinity for bone hydroxyapatite crystals. Thus, they have been used as a carrier for radio nucleotides to develop novel approaches of bone imaging. BPs exert also indirect anti-tumour activities in vivo. Indeed, BPs directly interfere with the bone microenvironment and target osteoclasts, endothelial cells and immune cells (tumour-associated macrophages, γ9δ2 T cells). BPs induce tumour cell death in vitro and same activity is suspected in vivo. The present review summarizes the mechanisms of actions of BPs as well as their clinical interests in bone primary tumours.

Keywords: Bisphosphosphonates, primary bone tumors, sarcoma, giant cell tumor of bone, Bone Tumours, teosarcoma, sarcomas, vicious cycle, osteoclasts, bone hydroxyapatite crystals, malformations, chondroma, chondrosarcoma, osteoblastic lesions, osteoclastic-activating factors, osteoblast, osteoclast functions, malignant diseases, nitrogen-containing bisphosphonate, Giant cell tumours (GCT), osteoclastogenesis, reconstruction techniques, osteoclast apoptosis, risedronate, ibandronate, minodronate, Fas gene expression, edematous mitochondria, caspase-3 activation, annexin-V, fibrous dysplasia, osteosarcoma, chondroblastic, osteoblastic components, myeloma, prostate carcino-mas, opment, multidrug resistance (MDR), Dendritic cells, dog osteosarcoma devel

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Article Details

VOLUME: 16
ISSUE: 27
Year: 2010
Page: [2981 - 2987]
Pages: 7
DOI: 10.2174/138161210793563554
Price: $58

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