MicroRNAs: Macro Challenges on Understanding Human Biological Functions and Neurological Diseases

Author(s): C. B. Santos-Reboucas, M. M.G. Pimentel.

Journal Name: Current Molecular Medicine

Volume 10 , Issue 8 , 2010

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Abstract:

MicroRNAS (miRNAs) are a class of endogenously single-stranded non-coding RNA molecules that can negatively modulate the expression of target messenger RNAs by 3´ UTR base pairing. During the processing of a miRNA, a network of orchestrated molecular events provides a dynamic manner to posttranscriptionally modulate gene expression. Recent research has demonstrated that although these molecules are small, they are involved in several crucial biological functions, as well as, in a broad spectrum of human diseases. In this review, we highlighted the current knowledge on the miRNA pathway field, focusing on how the disruption of the miRNA-mediated silencing pathways could lead to the pathogenesis of neurological disorders. The potential use of miRNAs as diagnostic/prognostic markers and the possibility of reversing the effects of some miRNA polymorphisms/mutations by promising therapeutics procedures have brought new perspectives into the treatment of human pathologies.

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Article Details

VOLUME: 10
ISSUE: 8
Year: 2010
Page: [692 - 704]
Pages: 13
DOI: 10.2174/156652410793384169
Price: $58

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