Lipid Rafts and Redox Regulation of Cellular Signaling in Cholesterol Induced Atherosclerosis

Betul      Catalgol; Nesrin      Kartal Ozer

Abstract

Redox mediated signaling mechanisms play crucial roles in the pathogenesis of several cardiovascular diseases. Atherosclerosis is one of the most important disorders induced mainly by hypercholesterolemia. Oxidation products and related signaling mechanisms are found within the characteristic biomarkers of atherosclerosis. Several studies have shown that redox signaling via lipid rafts play a significant role in the regulation of pathogenesis of many diseases including atherosclerosis. This review attempts to summarize redox signaling and lipid rafts in hypercholesterolemia induced atherosclerosis.

Keywords: Atherosclerosis, hypercholesterolemia, lipid rafts, reactive species, redox regulation, signaling, tunica intima, macrophage foam, proteoglycan, atherosclerotic lesions, Macrophages, Hyperlipidemia, hydroxydeoxyguanosine, isoprostanes, nonenzymatically, cyclooxygenase, lipoxygenase, dehydrogenase, thrombin, hypoxia-reoxygenation, cytochrome, nonphagocytic, Myeloperoxidases (MPO), Lipoxygenases, neovascularization, peroxynitryl, cyclooxygenase-2, rosiglitazone, flavoprotein, ribonucleotide reductase, (thioltransferase), transmembrane signaling, phospholipids, glycosylphosphatidylinositol, catalyzed cleavage, sphingomyelinase, sphingomyelinase-treated, lipid raft-dependent, polymerization, crosslinking, intracellular, Results demonstrated