The Role of T-Helper Cells in Atherosclerosis

Author(s): X. Lu, D. Lu, U. Narayan, V. V. Kakkar.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Volume 9 , Issue 1 , 2011

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Abstract:

Atherosclerosis is rapidly gaining recognition as an inflammatory disease showing contribution from innate and adaptive immunity pathways towards disease initiation and progression. Components of adaptive immunity especially T cells, are shown to be involved in atherogenesis and subsets of T cells are known to drive/ dampen inflammatory processes in atherosclerosis. However, the regulatory balance between the T cell subsets remains unclear. In this review, we summarize the role of T helper cells Th1, 2, 3 and 17, and regulatory cells Treg in atherosclerosis by studying the cytokines involved in Th cell functioning. We further examine the diverse roles of T helper cells for regulating the progression of atherosclerosis.

Keywords: T-helper cell, atherosclerosis, cytokine, cluster of differentiation, T regulation cells, inflammatory disease, adaptive immunity, lymphocytes, leukocyte, immune system, cell-mediated immune responses, Th2 cells, humoral immune response, human atheromatous plaques, Cellular Adhesion Molecules, monocytes, macrophages, B-lymphocytes, dendritic cells, major histocompatibility complex, interferon, transforming growth factor, immunoglobulins, low-density lipoprotein receptor, apolipoprotein E, 2-glycoprotein I, rheumatoid arthritis, antiphospholipid syndrome, IFN, Natural killer T, antigen presenting cells, HMG-CoA, ApoE, P. gingivalis, CCR5, CD195, glycosaminoglycan hyaluronan, CD40, MHC II, CD80, CD86, TLR4 expression, abdominal aortic aneurysms, NF-B binding sites, oxLDL antibodies, malondialdehyde-LDL-specific, Treg cells, pro-inflammatory cytokines, Drosophila, C. pneumoniae, atherosclerotic lesions, delayed-type hypersensitivity, Inducible nitric oxide synthase, Lipopolysaccharide, Monocyte chemoattractant protein-1

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2011
Page: [25 - 41]
Pages: 17
DOI: 10.2174/187152511794182819

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