Abstract
Plant-derived natural products have been an important source of several clinically useful anti-cancer agents. Plants continue to play a major role in drug discovery as evidenced by the number of promising new agents in clinical development based on selective activity against cancer-related molecular targets. Due to improvements in tumor targeting technology, some agents which failed in earlier clinical studies are also stimulating renewed interest. We wish to draw the attention of readers to the rapidly evolving recognition that a significant number of natural product drugs/leads are possibly produced by endophytic fungi and microbes residing in the plant tissues. We consider that this area of natural product research should be expanded significantly.
Keywords: Plant-derived natural products, anticancer, antitumor, targeted agents, endophytes, Natural Products, Anticancer Drug, cancer-related molecular targets, natural product drugs, endophytic fungi, taxanes, camptothecins, bioactive compounds, semi-synthetic, synthetic analogs, tumor cells, competitive inhibition, Vinca Alkaloids, vinorelbine, cancers, leukemias, lymphomas, breast and lung cancers, Kaposi's sarcoma, Epi-Podophyllotoxins, podophyllotoxin, etoposide, teniposide, colorectal cancers, Plant-derived Clinical Agents, homoharringtonine (HHT), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), complete hematologic remission (CHR), elliptinium (Celiptium), Combretastatins, combretistatin A4 phosphate (CA4), flavopriidol (Alvocidib), rohitukine, olomucine, roscovitine, purvalanol A purvalanol B, Ingenol-3-Angelate, Triptolide, maytansine, Bruceantin, Indirubins, 6-bromoindirubin, 6-bromoindirubin oxime, Silvestrol, epi-Silvestrol, withacnistin A, Emericellamide A
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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