Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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The Role of Oxidative Stress and Anti-Oxidant Treatment in Platinum-Induced Peripheral Neurotoxicity

Author(s): V. A. Carozzi, P. Marmiroli, G. Cavaletti.

Abstract:

Platinum-based anticancer drugs are a cornerstone of the current antineoplastic treatment. However, their use is limited by the onset of peripheral nervous system dysfunction, which can be severe and persistent over a long period of time. Among the several hypotheses proposed to explain this side effect, evidence is increasing that dorsal root ganglia (DRG) oxidative stress can be an important pathogenetic mechanism and, possibly, a therapeutic target to limit the severity of platinum-induced peripheral neurotoxicity but preserving the anticancer effectiveness. In fact, DRG energy failure has been suggested as a result of mitochondrial DNA-platinum binding and several antioxidant drugs have been tested in pre-clinical experiments and clinical trials. In this review, an update on the current knowledge on the relationship existing between oxidative stress and platinum drugs peripheral neurotoxicity will be given.

Keywords: Platinum-compounds, chemotherapy, peripheral neurotoxicity, experimental models, oxidative stress, antioxidants, compounds, experimental, dorsal root ganglia (DRG), cisplatin, carboplatin, oxaliplatin, (reactive oxygen species, ROS), superoxide-generating enzymes RENOX, Bcl-xlApe1), (BER), (GSH), (NAC), Glutathione, Tocopherol (Vitamin E), N-Acetyl-Cysteine, Lipoic Acid, Acetyl-L-Carnitine, Ginkgo Extract, EGb761, NCV, NAC

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Article Details

VOLUME: 10
ISSUE: 7
Year: 2010
Page: [670 - 682]
Pages: 13
DOI: 10.2174/156800910793605820
Price: $58