Triglyceride Level Affecting Shared Susceptibility Genes in Metabolic Syndrome and Coronary Artery Disease

P.      Kisfali; N.      Polgar; E.      Safrany; K.      Sumegi; B      I. Melegh; J.      Bene; A.      Weber; K.      Hetyesy; B.      Melegh

Abstract

Metabolic syndrome is characterized primarily by abdominal obesity, high triglyceride- and low HDL cholesterol levels, elevated blood pressure, and increased fasting glucose levels, which are often associated with coronary heart diseases. Several factors, such as physical inactivity, age, and several endocrine and genetic factors can increase the risk of the development of the disease. Gathered evidence shows, that metabolic syndrome is not only a risk factor for cardiovascular disease, but often both of them have the same shared susceptibility genes, as several genetic variants have shown a predisposition to both diseases. Due to the spread of robust genome wide association studies, the number of candidate genes in metabolic syndrome and coronary heart disease susceptibility increases very rapidly. From the growing spectrum of the genes influencing lipid metabolism (like the LPL; PPARA; APOE; APOAI/CIII/AIV genecluster and APOA5), the current review focuses on shared susceptibility variants involved in triglyceride metabolism and consequently the effects on the circulating triglyceride levels. As the elevated levels of triglycerides can be associated with disease phenotypes, some of these SNPs can have susceptibility features in both metabolic syndrome and in coronary heart disease, thereby some of them can even represent a kind of susceptibility link between metabolic syndrome and coronary artery disease.

Keywords: Atherosclerosis, Gene, Metabolic syndrome, SNP, Hypertriglyceridemia, Susceptibility Genes, Coronary Artery Disease, abdominal obesity, Atherosclerosis, Gene, hyper-tension, dyslipidemia, central obesity, low-density lipoprotein (VLDL), low-density lipopro-tein (LDL), high density lipoprotein (HDL), Apolipoprotein C, Apolipoprotein A5, Apolipoprotein E, Lipoprotein Lipase, Adipose Triglyceride Lipase, Glucokinase Regulatory Protein, plasma triglicerides, Angiopoietin-Like 3, Human Tribbles, –, 1, FADS Gene Cluster, arachidonic acid (AA)