Targeting Protein-Protein Interactions: A Promising Avenue of Anti-HIV Drug Discovery

Author(s): Peng Zhan, Wenjun Li, Hongfei Chen, Xinyong Liu.

Journal Name: Current Medicinal Chemistry

Volume 17 , Issue 29 , 2010

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Abstract:

In recent years, the number of useful chemical biology information of protein-protein interactions in the HIV life cycle and related inhibitors, is growing rapidly, which makes protein-protein interactions a new investigative area for antiviral drug intervention. This review will summarize recent work in this field, mainly focusing on the utilization of small molecules targeted against a variety of protein-protein interactions that have great therapeutic feasibility for HIV infection, and lastly outline some other important protein-protein interactions with a potential to advance into novel anti- HIV drug targets in future.

Keywords: HIV, AIDS, drug design, drug targets, protein-protein interactions, inhibitor, Anti-HIV, anti-AIDS, reverse transcriptase, protease, integrase, CCR5 coreceptor, HAART), capsid protein, NF-B, Rev protein, RNase H, TEFb, allosteric site, GP120, –, CD4, (ELISA), Schiffs base linkage, Bris-tol-Myers Squibb, clinical trials, HIV-1 inhibition, MAPPIT, HIV enzymes, Dimerization Inhibitors, HIV therapy, peptidomimetics, PR dimerization inhibitors, SAR, VIF-APOBEC3G, LEDGF/p75, CHIBA-3003, SQs, cell-based assays, (Vpr), Gag, GAG-TSG101, CRM1-NES

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Article Details

VOLUME: 17
ISSUE: 29
Year: 2010
Page: [3393 - 3409]
Pages: 17
DOI: 10.2174/092986710793176357
Price: $58

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