Ontologies of Drug Discovery and Design for Neurology, Cardiology and Oncology

Author(s): Jose M. Vazquez-Naya, Marcos Martinez-Romero, Ana B. Porto-Pazos, Francisco Novoa, Manuel Valladares-Ayerbes, Javier Pereira, Cristian R. Munteanu, Julian Dorado.

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 24 , 2010

Abstract:

The complex diseases in the field of Neurology, Cardiology and Oncology have the most important impact on our society. The theoretical methods are fast and they involve some efficient tools aimed at discovering new active drugs specially designed for these diseases. The ontology of all the items that are linked with the molecule metabolism and the treatment of these diseases gives us the possibility to correlate information from different levels and to discover new relationships between complex diseases such as common drug targets and disease patterns. This review presents the ontologies used to process drug discovery and design in the most common complex diseases.

Keywords: Drug design, ontology, prostaglandin synthases, complex disease, Alzheimer, ’, s disease, Parkinson, multi-factorial diseases, Drug Discovery Investigations ontology (DDI), Protein Modification (PSI-MOD), Protein Ontology (PRO), National Drug Data File (NDDF), Drug Interaction Ontology (DIO), NCI Thesaurus (NCI-T), SNOMED-CT, RxNorm, NDF, EBI, (ICD-NA)

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Article Details

VOLUME: 16
ISSUE: 24
Year: 2010
Page: [2724 - 2736]
Pages: 13
DOI: 10.2174/138161210792389199
Price: $58

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