Abstract
Thermo, pH and magnetic field responsive core-shell particles of poly(acrylonitrile-co-N-isopropylacrylamide (p(AN-c- NIPAM)) were synthesized by microemulsion polymerization. Fe3O4 nanomagnetic particles were encapsulated inside core-shell polymeric particles during the polymerization and simultaneous crosslinking reaction of AN and NIPAM using ethylene glycol dimethacrylate (EGDMA) as a crosslinker and ammonium persulfate (APS) as initiator. To increase the hydrophilicity of the particles, the hydrophobic core, which contains nitrile groups were converted to the amidoxime group by amidoximation reaction and the conversion, was confirmed by FT-IR and swelling experiments. To demonstrate the usage of the synthesized particles as potential guided drug delivery vehicles, a calcium channel blocker, Verapamil, was used for in vitro drug release studies from p(AN-c-NIPAM), amidoximated p(AN-c- NIPAM) and composite p(AN-c-NIPAM) particle systems in phosphate buffer solution (PBS) at two different temperatures, at room (~25°C) and 40°C ( > LCST: Lower Critical Solution Temperature of p(NIPAM)), respectively.
Keywords: Soft-nanoparticles, drug-release, magnetic, nanocomposites, multifunctional, microgel, Soft Core-Shell, Polymeric Nanoparticles, Potential Guided Drug Delivery, microemulsion polymerization, hydrophobic core, calcium channel blocker, Verapamil, amidoximated p(AN-c-NIPAM), composite p(AN-c-NIPAM), “intelligent” materials, polymer gel, Lower Critical Solution Temperature (LCST), volume phase transition (VPT), nanobiomedical devices, magnetic nanoparticles, Amidoximation Reaction, Drug Loading, Nanogel particle, polydispersities, Hydrogel
Current Nanoscience
Title: Soft Core-Shell Polymeric Nanoparticles with Magnetic Property for Potential Guided Drug Delivery
Volume: 6 Issue: 5
Author(s): Nurettin Sahiner and Pinar Ilgin
Affiliation:
Keywords: Soft-nanoparticles, drug-release, magnetic, nanocomposites, multifunctional, microgel, Soft Core-Shell, Polymeric Nanoparticles, Potential Guided Drug Delivery, microemulsion polymerization, hydrophobic core, calcium channel blocker, Verapamil, amidoximated p(AN-c-NIPAM), composite p(AN-c-NIPAM), “intelligent” materials, polymer gel, Lower Critical Solution Temperature (LCST), volume phase transition (VPT), nanobiomedical devices, magnetic nanoparticles, Amidoximation Reaction, Drug Loading, Nanogel particle, polydispersities, Hydrogel
Abstract: Thermo, pH and magnetic field responsive core-shell particles of poly(acrylonitrile-co-N-isopropylacrylamide (p(AN-c- NIPAM)) were synthesized by microemulsion polymerization. Fe3O4 nanomagnetic particles were encapsulated inside core-shell polymeric particles during the polymerization and simultaneous crosslinking reaction of AN and NIPAM using ethylene glycol dimethacrylate (EGDMA) as a crosslinker and ammonium persulfate (APS) as initiator. To increase the hydrophilicity of the particles, the hydrophobic core, which contains nitrile groups were converted to the amidoxime group by amidoximation reaction and the conversion, was confirmed by FT-IR and swelling experiments. To demonstrate the usage of the synthesized particles as potential guided drug delivery vehicles, a calcium channel blocker, Verapamil, was used for in vitro drug release studies from p(AN-c-NIPAM), amidoximated p(AN-c- NIPAM) and composite p(AN-c-NIPAM) particle systems in phosphate buffer solution (PBS) at two different temperatures, at room (~25°C) and 40°C ( > LCST: Lower Critical Solution Temperature of p(NIPAM)), respectively.
Export Options
About this article
Cite this article as:
Sahiner Nurettin and Ilgin Pinar, Soft Core-Shell Polymeric Nanoparticles with Magnetic Property for Potential Guided Drug Delivery, Current Nanoscience 2010; 6 (5) . https://dx.doi.org/10.2174/157341310797574998
DOI https://dx.doi.org/10.2174/157341310797574998 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Is Preoperative Endoscopic Biliary Drainage Indicated for Jaundiced Patients with Resectable Pancreatic Cancer?
Current Drug Targets Editorial [Hot topic: Current Formulations and Techniques of Drug/gene Delivery for Targeted Therapy and Tissue Engineering (Executive Editors: Chi-Hwa Wang and Sudhir H. Ranganath)]
Current Pharmaceutical Design Structural Investigation of Proapoptotic Peptide by Cd and Nmr Spectroscopy
Protein & Peptide Letters Natural Radioprotective Agents: An Overview
Current Organic Chemistry Design, Synthesis and Anticancer Evaluation of Acetamides Comprising 1,2,3-triazole, 1,3,4-thiadiazole and Isothiazolo[4,3-b]pyridine Rings
Letters in Organic Chemistry Anticancer Drug Sensitivity Testing, a Historical Review and Future Perspectives
Current Drug Therapy Diaryl Urea: A Privileged Structure in Anticancer Agents
Current Medicinal Chemistry An Overview on Fibroblast Growth Factors: Structural, Functional and Therapeutic Implications
Current Proteomics The Hidden Face of Fetal Alcohol Spectrum Disorder
Current Women`s Health Reviews Synthesis and Anti-cancer Activity of 3-substituted Benzoyl-4-substituted Phenyl-1H-pyrrole Derivatives
Anti-Cancer Agents in Medicinal Chemistry Polymer-Drug Nanoconjugate – An Innovative Nanomedicine: Challenges and Recent Advancements in Rational Formulation Design for Effective Delivery of Poorly Soluble Drugs
Pharmaceutical Nanotechnology Editorial (Thematic Issue:Nanotechnology for Drug Delivery: Part III)
Current Pharmaceutical Design Separating Fact from Fiction: Assessing the Potential of Modified Adenovirus Vectors for Use in Human Gene Therapy
Current Gene Therapy Perfluoroalkylsulfonyloxyisoflavones: Synthesis and Anti-Proliferation of HL-60
Letters in Organic Chemistry Sex Steroid Hormones, Cardiovascular Diseases and The Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry TNF as a Target of Inflammation in Rheumatoid Arthritis
Endocrine, Metabolic & Immune Disorders - Drug Targets A Novel Polyarginine Containing Smac Peptide Conjugate that Mediates Cell Death in Tumor and Healthy Cells
Medicinal Chemistry miR-149 as a Potential Molecular Target for Cancer
Current Medicinal Chemistry Identification of Two Novel Mutations in the <i>ATM</i> Gene from Patients with Ataxia-Telangiectasia by Whole Exome Sequencing
Current Genomics Signaling of MiRNAs-FOXM1 in Cancer and Potential Targeted Therapy
Current Drug Targets