Abstract
Algae are eaten as healthy foods in Asian countries. We summarize our recent results on the immunoregulatory role of polysaccharide fractions from edible algae on immediate hypersensitivity, delayed-type hypersensitivity, and antitumor immune responses. They are divided into two types. One is to manipulate immune response through toll-like receptor 4 (TLR 4). The other uses different receptors to modify the immune response. Petalonia binghamiae polysaccharide fraction and Spirulina pacifica complex polysaccharide attenuate the delayed-type hypersensitivity and tumor growth by reducing the production of inflammatory cytokine, IL-17 through TLR4. This is suggested from the results that these polysaccharide fractions could suppress the delayed-type hypersensitivity and tumor growth in C3H/HeN but not in tolllike receptor 4 mutant, C3H/HeJ mice. Alginic acid, the polysaccharide from brown algae suppressed tumor growth in both C3H/HeN and C3H/HeJ mice and did not suppress delayed-type hypersensitivity response significantly, when administered intraperitoneally. We propose the potential usefulness of edible algae as the fine tuning reagents of the immune response. We also summarize the recent advancement in the area of regulation of immune responses in relation to these polysaccharides.
Keywords: Algae, allergic responses, IL-17, inflammation, polysaccharide, TLR, tumor
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Effects of Edible Algae Polysaccharides on Allergic, Inflammatory, and Anti-Tumor Responses Through Toll-Like Receptor 4
Volume: 9 Issue: 3
Author(s): Akira Tominaga, Hiromi Okuyama, Satoshi Fukuoka, Takahiro Taguchi, Yutaka Kusumoto, Keiji Shimizu and Shiro Ono
Affiliation:
Keywords: Algae, allergic responses, IL-17, inflammation, polysaccharide, TLR, tumor
Abstract: Algae are eaten as healthy foods in Asian countries. We summarize our recent results on the immunoregulatory role of polysaccharide fractions from edible algae on immediate hypersensitivity, delayed-type hypersensitivity, and antitumor immune responses. They are divided into two types. One is to manipulate immune response through toll-like receptor 4 (TLR 4). The other uses different receptors to modify the immune response. Petalonia binghamiae polysaccharide fraction and Spirulina pacifica complex polysaccharide attenuate the delayed-type hypersensitivity and tumor growth by reducing the production of inflammatory cytokine, IL-17 through TLR4. This is suggested from the results that these polysaccharide fractions could suppress the delayed-type hypersensitivity and tumor growth in C3H/HeN but not in tolllike receptor 4 mutant, C3H/HeJ mice. Alginic acid, the polysaccharide from brown algae suppressed tumor growth in both C3H/HeN and C3H/HeJ mice and did not suppress delayed-type hypersensitivity response significantly, when administered intraperitoneally. We propose the potential usefulness of edible algae as the fine tuning reagents of the immune response. We also summarize the recent advancement in the area of regulation of immune responses in relation to these polysaccharides.
Export Options
About this article
Cite this article as:
Tominaga Akira, Okuyama Hiromi, Fukuoka Satoshi, Taguchi Takahiro, Kusumoto Yutaka, Shimizu Keiji and Ono Shiro, Effects of Edible Algae Polysaccharides on Allergic, Inflammatory, and Anti-Tumor Responses Through Toll-Like Receptor 4, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2010; 9 (3) . https://dx.doi.org/10.2174/1871523011009030238
DOI https://dx.doi.org/10.2174/1871523011009030238 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Evaluation of Non-Coding RNAs as Potential Targets in Head and Neck Squamous Cell Carcinoma Cancer Stem Cells
Current Drug Targets Caspases as Drug Targets in Ischemic Organ Injury
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Base Excision Repair: Contribution to Tumorigenesis and Target in Anticancer Treatment Paradigms
Current Medicinal Chemistry Carbonic Anhydrase Inhibitors and the Management of Cancer
Current Topics in Medicinal Chemistry Coexistence of Type-1 Diabetes Mellitus and Papillary Thyroid Carcinoma
Current Diabetes Reviews Hybrid Imaging in Evaluation of Abdominal Sarcoidosis
Current Medical Imaging Opportunities to Improve the Prevention and Treatment of Cervical Cancer
Current Molecular Medicine Is the Cytoskeleton an Intracellular Receptor for Adrenomedullin and PAMP?
Current Protein & Peptide Science Berberine Exhibits Antitumor Effects in Human Ovarian Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Biotransformations of Prenylated Hop Flavonoids for Drug Discovery and Production
Current Drug Metabolism Peptidic Tumor Targeting Agents: The Road from Phage Display Peptide Selections to Clinical Applications
Current Pharmaceutical Design Regulation of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids
Mini-Reviews in Medicinal Chemistry Comprehensive Comparison of Trace Metal Concentrations in Cancerous and Non-Cancerous Human Tissues
Current Medicinal Chemistry Tumor Immune Escape Mechanisms that Operate During Metastasis
Current Pharmaceutical Biotechnology Piceatannol Modulates Lung Epithelial Cellular Responses to Pseudomonas aeruginosa
Inflammation & Allergy - Drug Targets (Discontinued) DNA Repair Inhibitors: The Next Major Step to Improve Cancer Therapy
Current Topics in Medicinal Chemistry The Molecular Basis of Notch Signaling Regulation: A Complex Simplicity
Current Molecular Medicine Mesenchymal Stem Cells of Dental Origin-Their Potential for Antiinflammatory and Regenerative Actions in Brain and Gut Damage
Current Neuropharmacology Molecular Docking, Antioxidant, Anticancer and Antileishmanial Effects of Newly Synthesized Quinoline Derivatives
Anti-Cancer Agents in Medicinal Chemistry Synthesis of 1,3,6-Trioxygenated Prenylated Xanthone Derivatives as Potential Antitumor Agents
Letters in Organic Chemistry