Abstract
Increasing evidence suggests that activation of the innate immune system may play a seminal role in the pathophysiology of depression. Several lines of evidence support the association of inflammation and depression. Peripheral administration of cytokines, such as interferon-alpha, can induce many of the symptoms of the depressive syndrome. In addition, medically healthy patients with major depression exhibit elevated plasma levels of proinflammatory cytokines. Moreover, cytokines produce effects on a variety of neurobiological substrates previously implicated in the pathogenesis of depression. Thus, proinflammatory cytokines alter neuroendocrine function, several neurotransmitter systems including dopamine and glutamate, neural plasticity, and neuronal activity in limbic regions. The burgeoning evidence that depression is an inflammatory disease is reviewed.
Keywords: Inflammation, cytokines, depression, monoamine neurotransmitters, hypothalamic-pituitary-adrenal axis, glutamate.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Inflammation and Mood Disorders: Proinflammatory Cytokines and the Pathogenesis of Depression
Volume: 9 Issue: 3
Author(s): M. Beatriz Currier and Charles B. Nemeroff
Affiliation:
Keywords: Inflammation, cytokines, depression, monoamine neurotransmitters, hypothalamic-pituitary-adrenal axis, glutamate.
Abstract: Increasing evidence suggests that activation of the innate immune system may play a seminal role in the pathophysiology of depression. Several lines of evidence support the association of inflammation and depression. Peripheral administration of cytokines, such as interferon-alpha, can induce many of the symptoms of the depressive syndrome. In addition, medically healthy patients with major depression exhibit elevated plasma levels of proinflammatory cytokines. Moreover, cytokines produce effects on a variety of neurobiological substrates previously implicated in the pathogenesis of depression. Thus, proinflammatory cytokines alter neuroendocrine function, several neurotransmitter systems including dopamine and glutamate, neural plasticity, and neuronal activity in limbic regions. The burgeoning evidence that depression is an inflammatory disease is reviewed.
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Beatriz Currier M. and B. Nemeroff Charles, Inflammation and Mood Disorders: Proinflammatory Cytokines and the Pathogenesis of Depression, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2010; 9 (3) . https://dx.doi.org/10.2174/1871523011009030212
DOI https://dx.doi.org/10.2174/1871523011009030212 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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