Effect of Particle Formulation on Dry Powder Inhalation Efficiency

Author(s): Meer Saiful Hassan, Raymond Lau.

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 21 , 2010

Abstract:

Dry powder inhalation has good potential to be an alternative route of drug administration, especially for the treatment of lung and systemic diseases. However, typically only a small fraction of the dose can be delivered to the lower airways. Continuous effort on the drug formulation is undergoing to improve the deep lung deposition. Key properties of the drug and carrier particles and their relationships with the particle dispersibility and deposition properties in the lung are discussed individually. Some recent drug formulation techniques for dry powder inhalation are also reviewed.

Keywords: Pulmonary drug delivery, dry powder inhalation, drug formulation, particle characteristics, particle interactions

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Article Details

VOLUME: 16
ISSUE: 21
Year: 2010
Page: [2377 - 2387]
Pages: 11
DOI: 10.2174/138161210791920423
Price: $58

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