Remarkable Catalytic Activity of Sodium-Modified-Hydroxyapatite in the Synthesis of α-Hydroxyphosphonates

Author(s): A. Solhy, S. Sebti, R. Tahir, J. Sebti, M. Ould Abba, M. Bousmina, S. Vaudreuil, M. Zahouily.

Journal Name: Current Organic Chemistry

Volume 14 , Issue 14 , 2010

Abstract:

A green protocol for the synthesis of α-hydroxyphosphonates by condensation of carbonyl compounds on dialkylphosphites, under solvent free conditions, has been described using hydroxyapatite (HAP) catalysts. This condensation proceeds with excellent yields and 100% atom economy. The best results were obtained using Na-modified-hydroxyapatite (Na-HAP) catalyst. Furthermore, being heterogeneous in nature, these catalysts are easily separated from the reaction mixture and reused several times without any loss of activity, especially for Na-HAP, after being washed by acetone and calcined at 700°C.

Keywords: Hydroxyapatite, Sodium-Hydroxyapatite, α-hydroxyphosphonates, Heterogeneous Catalysis, Dry Media, Green Synthesis

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Article Details

VOLUME: 14
ISSUE: 14
Year: 2010
Page: [1517 - 1522]
Pages: 6
DOI: 10.2174/138527210791616821
Price: $58

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