New Trends in Non-Aqueous Biocatalysis

Author(s): Hui-Lei Yu, Ling Ou, Jian-He Xu.

Journal Name: Current Organic Chemistry

Volume 14 , Issue 14 , 2010

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It is now well known that non-aqueous biocatalysis has emerged as an important area of systematic research and industrial development over the last two decades, fueled mainly by chemical and pharmaceutical interest. The non-aqueous biocatalysis boasts many potential advantages, including higher substrate solubility, reversal of hydrolytic reactions and modified enzyme specificity. As a consequence, applications of enzymatic catalysis in organic solvents range from chiral resolution of pharmaceuticals and their intermediates to enantio- or regio-selective synthesis of these substances. In this review, recent trends of biocatalyst engineering and solvent engineering in non-aqueous biocatalysis, diversified enzyme reactions for non-aqueous biocatalysis and a greener need for it have been discussed in detail with new examples.

Keywords: Non-aqueous biocatalysis, Biphasci reaction, Lipase, Reductase, Oxidizing enzyme, Ionic liquids, Green chemistry

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Article Details

Year: 2010
Page: [1424 - 1432]
Pages: 9
DOI: 10.2174/138527210791616740
Price: $58

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