Abstract
Understanding the global gene expression profile of stem cells and their multilineage differentiation will be essential for their ultimate therapeutic application. Efforts to characterize stem cells have relied on analyzing the genomewide expression profiles that are biased towards the identification of genes that display the most pronounced differential expression. Rather than being viewed as a “blank” state, recent studies suggest that stem cells express low levels of multiple lineage specific genes prior to differentiation, a phenomenon known as “lineage priming.” It is not likely that low levels of lineage-specific genes produce sufficient amounts of differentiation factors, but rather to provide rapid transcription to a wide range of lineage programs prior to differentiation. Thus, stem cell differentiation may involve the elimination of other potential pathways and the activation of a specific lineage program.
Keywords: Microarrays, differentiation, regenerative medicine, tissue engineering
Current Genomics
Title: Functional Genomics: New Insights into the Function of Low Levels of Gene Expression in Stem Cells
Volume: 11 Issue: 5
Author(s): Jennifer A. Hipp, Jason D. Hipp, Anthony Atala and Shay Soker
Affiliation:
Keywords: Microarrays, differentiation, regenerative medicine, tissue engineering
Abstract: Understanding the global gene expression profile of stem cells and their multilineage differentiation will be essential for their ultimate therapeutic application. Efforts to characterize stem cells have relied on analyzing the genomewide expression profiles that are biased towards the identification of genes that display the most pronounced differential expression. Rather than being viewed as a “blank” state, recent studies suggest that stem cells express low levels of multiple lineage specific genes prior to differentiation, a phenomenon known as “lineage priming.” It is not likely that low levels of lineage-specific genes produce sufficient amounts of differentiation factors, but rather to provide rapid transcription to a wide range of lineage programs prior to differentiation. Thus, stem cell differentiation may involve the elimination of other potential pathways and the activation of a specific lineage program.
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Cite this article as:
A. Hipp Jennifer, D. Hipp Jason, Atala Anthony and Soker Shay, Functional Genomics: New Insights into the Function of Low Levels of Gene Expression in Stem Cells, Current Genomics 2010; 11 (5) . https://dx.doi.org/10.2174/138920210791616680
DOI https://dx.doi.org/10.2174/138920210791616680 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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