Abstract
Rottlerin is a natural polyphenolic compound, which was initially indicated and marketed as a PKC δ inhibitor and recently proposed and patented as an anti-hypertensive drug. In vitro results from our Laboratory and data from the literature suggest a potential use of Rottlerin in the treatment/control of psoriasis, a skin disease characterized by abnormal cellular proliferation, abnormal angiogenesis and inflammation. Rottlerin, indeed, is an antioxidant and a potent inhibitor of the transcription factor NFκB, a key mediator of immune responses and a crucial regulator of cell cycle and apoptosis in immune cells, endothelial cells and keratinocytes. Herein, we will review the multiple activities of Rottlerin (antioxidant, antiproliferative, antiangiogenic and anti-inflammatory) that give to the drug the potential to be used as a new therapeutic approach against psoriasis.
Keywords: Rottlerin, NFκB, Inflammation, Angiogenesis, Proliferation
Current Drug Metabolism
Title: Rottlerin: Bases for a Possible Usage in Psoriasis
Volume: 11 Issue: 5
Author(s): Emanuela Maioli and Giuseppe Valacchi
Affiliation:
Keywords: Rottlerin, NFκB, Inflammation, Angiogenesis, Proliferation
Abstract: Rottlerin is a natural polyphenolic compound, which was initially indicated and marketed as a PKC δ inhibitor and recently proposed and patented as an anti-hypertensive drug. In vitro results from our Laboratory and data from the literature suggest a potential use of Rottlerin in the treatment/control of psoriasis, a skin disease characterized by abnormal cellular proliferation, abnormal angiogenesis and inflammation. Rottlerin, indeed, is an antioxidant and a potent inhibitor of the transcription factor NFκB, a key mediator of immune responses and a crucial regulator of cell cycle and apoptosis in immune cells, endothelial cells and keratinocytes. Herein, we will review the multiple activities of Rottlerin (antioxidant, antiproliferative, antiangiogenic and anti-inflammatory) that give to the drug the potential to be used as a new therapeutic approach against psoriasis.
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Cite this article as:
Maioli Emanuela and Valacchi Giuseppe, Rottlerin: Bases for a Possible Usage in Psoriasis, Current Drug Metabolism 2010; 11 (5) . https://dx.doi.org/10.2174/138920010791526097
DOI https://dx.doi.org/10.2174/138920010791526097 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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