Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Overcoming Endocrine Resistance in Breast Cancer

Author(s): R.A. Madaio, G. Spalletta, L. Cravello, M. Ceci, L. Repetto, G. Naso.

Abstract:

Approximately 70% of breast cancers express the estrogen receptor (ER) and endocrine therapy is the most important component of systemic therapy for hormone-responsive breast cancer. Unfortunately, endocrine-resistant ER-positive disease represents up to one-quarter of all breast cancers and a number of different mechanisms have been implicated in endocrine resistance, either intrinsic, occurring de novo at the initial exposure to endocrine therapies or acquired, occurring after an initial response to therapy. In the present work a number of molecular mechanisms accounting for intrinsic and acquired resistance to hormonal therapies have been reviewed and the most promising strategies to overcome endocrine resistance have been highlighted.

Keywords: Estrogen receptor, hormone resistance, breast cancer

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2010
Page: [519 - 528]
Pages: 10
DOI: 10.2174/156800910791517226
Price: $58