Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard


Baculovirus as a Gene Delivery Vector for Cartilage and Bone Tissue Engineering

Author(s): Chin-Yu Lin, Chia-Hsin Lu, Wen-Yi Luo, Yu-Han Chang, Li-Yu Sung, Hsin-Yi Chiu, Yu-Chen Hu.


Baculovirus is an effective vector for gene delivery into various mammalian cells, including chondrocytes and mesenchymal stem cells, and has been employed for diverse applications. By gene delivery and expression of the growth factor, recombinant baculovirus has been shown to modulate the differentiation state of the cells and stimulates the production of extracellular matrix and tissue formation, hence repairing the damaged cartilage and bone in vivo. This article reviews the studies pertaining to the applications of baculovirus-mediated gene delivery in cartilage and bone tissue engineering and discusses recent progress, future applications and potential hurdles.

Keywords: Baculovirus, bone, cartilage, gene therapy, tissue engineering

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Article Details

Year: 2010
Page: [242 - 254]
Pages: 13
DOI: 10.2174/156652310791321242
Price: $58