Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Potential Cancer Gene Therapy by Baculoviral Transduction

Author(s): Shu Wang, Ghayathri Balasundaram.

Abstract:

Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor genes, to genes encoding tumor-specific antigens, have been successfully delivered by insect baculoviral vectors to treat tumours in animal models. These encouraging results observed to date underscore the potential for using the non-human baculovirus to combat human cancer. The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice.

Keywords: Baculovirus, viral vector, transduction, cancer therapy

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2010
Page: [214 - 225]
Pages: 12
DOI: 10.2174/156652310791321251
Price: $58