Abstract
Mono-aminergic neurotransmitters, in particular serotonin (5-HT), are involved in regulating a large number of psychological and physiological functions, and abnormal 5-HT transmission has been implicated in a wide variety of neuropsychiatric disorders. Positron emission tomography (PET) is a non-invasive nuclear imaging technique with exquisite sensitivity and specificity, allowing delineation of neurotransmitter function in vivo. Over the last two decades, PET has been used to investigate 5-HT function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, Alzheimers disease, and impulse control disorders. In the present review, an overview of recent findings is provided, and possibilities for further research are discussed.
Keywords: Serotonin, positron emission tomography, depression, schizophrenia, Alzheimer, epilepsy
Current Pharmaceutical Design
Title: Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings
Volume: 16 Issue: 18
Author(s): D.J. Veltman, H.G. Ruhe and J. Booij
Affiliation:
Keywords: Serotonin, positron emission tomography, depression, schizophrenia, Alzheimer, epilepsy
Abstract: Mono-aminergic neurotransmitters, in particular serotonin (5-HT), are involved in regulating a large number of psychological and physiological functions, and abnormal 5-HT transmission has been implicated in a wide variety of neuropsychiatric disorders. Positron emission tomography (PET) is a non-invasive nuclear imaging technique with exquisite sensitivity and specificity, allowing delineation of neurotransmitter function in vivo. Over the last two decades, PET has been used to investigate 5-HT function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, Alzheimers disease, and impulse control disorders. In the present review, an overview of recent findings is provided, and possibilities for further research are discussed.
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Cite this article as:
Veltman D.J., Ruhe H.G. and Booij J., Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings, Current Pharmaceutical Design 2010; 16 (18) . https://dx.doi.org/10.2174/138161210791293033
DOI https://dx.doi.org/10.2174/138161210791293033 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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