Microarray-Based Gene Expression Analysis of Hepatocellular Carcinoma

Author(s): Thorsten Maass, Ioannis Sfakianakis, Frank Staib, Markus Krupp, Peter R. Galle, Andreas Teufel.

Journal Name: Current Genomics

Volume 11 , Issue 4 , 2010

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Abstract:

Microarray studies have successfully shed light on various aspects of the molecular mechanisms behind the development of hepatocellular carcinoma (HCC), such as the identification of novel molecular subgroups and the genetic profiles associated with metastasis and venous invasion. These experiments, mainly comprising genome wide profiling, potentially represent the basis of novel targeted therapeutic strategies in HCC. In response, we summarize the multiple reported expression profiles in HCC associated with HCC development, novel subgroups, venous invasion and metastasis.

Keywords: HCC, systems biology, bioinformatics, oncogenomics

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2010
Page: [261 - 268]
Pages: 8
DOI: 10.2174/138920210791233063
Price: $58

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