Targeting Protein Tyrosine Phosphatases for Anticancer Drug Discovery

Author(s): Latanya M. Scott , Harshani R. Lawrence , Said M. Sebti , Nicholas J. Lawrence , Jie Wu .

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 16 , 2010

Abstract:

Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107 genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate various cellular activities essential for the initiation and maintenance of malignant phenotypes. While PTK inhibitors are now used routinely for cancer treatment, the PTP inhibitor development field is still in the discovery phase. In this article, the suitability of targeting PTPs for novel anticancer drug discovery is discussed. Examples are presented for PTPs that have been targeted for anticancer drug discovery as well as potential new PTP targets for novel anticancer drug discovery.

Keywords: Protein tyrosine phosphatase inhibitor, Shp2, PTP1B, Cdc14, PRL-3, LMW-PTP, Cdc25, eya

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Article Details

VOLUME: 16
ISSUE: 16
Year: 2010
Page: [1843 - 1862]
Pages: 20
DOI: 10.2174/138161210791209027
Price: $58

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