Recent Progress on Computer-Aided Inhibitor Design of H5N1 Influenza A Virus

Title: Recent Progress on Computer-Aided Inhibitor Design of H5N1 Influenza A Virus

Volume: 6 Issue: 2

Author(s): Xiaoli Guo, Jing-Fang Wang, Yisheng Zhu and Dong-Qing Wei

Affiliation:

Keywords: M2-ion channel inhibitors, NA inhibitors, H5N1 viruses, drug-resistance, adamantanes, oseltamivir, structure-based drug design

Abstract: Design of novel H5N1 inhibitors is currently a research topic of vital importance owing to both a recent pandemic threat by the worldwide spread of H5N1 avian influenza and the high resistance of H5N1 virus to the most widely used commercial drug, oseltamivir-OTV (Tamiflu). There has been much progress in this field recently. This review covers recent work on bioinformatics studies, structure based design, computer modeling and molecular dynamics simulations.

Cite this article as:

Guo Xiaoli, Wang Jing-Fang, Zhu Yisheng and Wei Dong-Qing, Recent Progress on Computer-Aided Inhibitor Design of H5N1 Influenza A Virus, Current Computer-Aided Drug Design 2010; 6 (2) . https://dx.doi.org/10.2174/157340910791202487