Abstract
Persistent human Papillomavirus (HPV) infections are now recognised as the leading cause of cervical cancer (CC). Approximately 100 types of human infecting HPV exist in nature and according to the samples collected from either pre-cancerous or cancerous lesions, almost ten are responsible for a good part of the CC cases. Two anti-HPV vaccines are currently registered worldwide - a tetravalent and a bivalent one - for which evidences of protecting effectiveness and safety have been delivered by controlled clinical trials and clinical practice. Consequently, and as a first step, several countries implemented HPV mass vaccination programmes for girls before the age of sexual debut. Moreover, and specifically for the bivalent vaccine, efficacy over various oncogenic types has been demonstrated in a broad population also including sexually active women that had potentially already acquired an HPV infection. The opportunity to extend the primary prevention to other cohorts of women up to the adult age through the use of the vaccine, improves the possibility to actively reduce the total number of CC cases. Based on two country examples, Italy and Belgium, different strategies for HPV vaccination of pre-adolescents, adolescents and young adults are discussed.
Keywords: Papillomavirus, anti-HPV vaccines, primary prevention, pre-adolescents, adolescents, young adults, immunogenic effects
Current Cancer Therapy Reviews
Title: HPV Vaccination in Adolescents: From Clinical Data to Implementation and Practice
Volume: 6 Issue: 2
Author(s): Franco Borruto and Karel Hoppenbrouwers
Affiliation:
Keywords: Papillomavirus, anti-HPV vaccines, primary prevention, pre-adolescents, adolescents, young adults, immunogenic effects
Abstract: Persistent human Papillomavirus (HPV) infections are now recognised as the leading cause of cervical cancer (CC). Approximately 100 types of human infecting HPV exist in nature and according to the samples collected from either pre-cancerous or cancerous lesions, almost ten are responsible for a good part of the CC cases. Two anti-HPV vaccines are currently registered worldwide - a tetravalent and a bivalent one - for which evidences of protecting effectiveness and safety have been delivered by controlled clinical trials and clinical practice. Consequently, and as a first step, several countries implemented HPV mass vaccination programmes for girls before the age of sexual debut. Moreover, and specifically for the bivalent vaccine, efficacy over various oncogenic types has been demonstrated in a broad population also including sexually active women that had potentially already acquired an HPV infection. The opportunity to extend the primary prevention to other cohorts of women up to the adult age through the use of the vaccine, improves the possibility to actively reduce the total number of CC cases. Based on two country examples, Italy and Belgium, different strategies for HPV vaccination of pre-adolescents, adolescents and young adults are discussed.
Export Options
About this article
Cite this article as:
Borruto Franco and Hoppenbrouwers Karel, HPV Vaccination in Adolescents: From Clinical Data to Implementation and Practice, Current Cancer Therapy Reviews 2010; 6 (2) . https://dx.doi.org/10.2174/157339410791202592
DOI https://dx.doi.org/10.2174/157339410791202592 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Advances In Developing Novel Anti-Cancer Drugs Targeting Tumor Hypoxic and Acidic Microenvironments
Recent Patents on Anti-Cancer Drug Discovery The Capsaicin Paradox: Pain Relief by an Algesic Agent
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Mast Cells and Basophils: Trojan Horses of Conventional Lin- Stem/Progenitor Cell Isolates
Current Pharmaceutical Design Cervical Squamous Intraepithelial Lesions Among HIV-Positive Women on Antiretroviral Therapy in Kenya
Current HIV Research Targeting the Cancer-Stroma Interaction: A Potential Approach for Pancreatic Cancer Treatment
Current Pharmaceutical Design Synthesis of 9-O-3-(1-piperazinyl/morpholinyl/piperidinyl)pentyl-berberines as Potential Antioxidant and Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry Key miRNAs in Modulating Aging and Longevity: A Focus on Signaling Pathways and Cellular Targets
Current Molecular Pharmacology Signal Transduction and Heavy Ion Radiation Therapy: Biological Mechanisms, Biological Quality Assurance, and New Multimodality Approach
Current Signal Transduction Therapy Oxidative Phosphorylation as a Target to Arrest Malignant Neoplasias
Current Medicinal Chemistry Ferrous Ion Chelating Modification and Treatment of Iron-Deficiency Anemia of Exopolysaccharide from Lachnum sp.
Current Chemical Biology Novel Compounds from Marine Microorganisms that Inhibit Mammalian DNA Polymerase
Current Organic Chemistry Focal Adhesion Kinase as a Cancer Therapy Target
Anti-Cancer Agents in Medicinal Chemistry Anti-EGFR Therapy: Strategies in Head and Neck Squamous Cell Carcinoma
Recent Patents on Anti-Cancer Drug Discovery The Application of lncRNAs in Cancer Treatment and Diagnosis
Recent Patents on Anti-Cancer Drug Discovery New Perspectives in the Pharmacological Potential of Naringin in Medicine
Current Medicinal Chemistry Review on Documented Medicinal Plants used for the Treatment of Cancer
Current Traditional Medicine Promotion of Cortico-Cerebral Precursors Expansion by Artificial pri-miRNAs Targeted Against the Emx2 Locus
Current Gene Therapy Synthesis of Aryl-Substituted Naphthalenoids as Potent Topoisomerase Inhibitors
Medicinal Chemistry Regulation of EMT by Notch Signaling Pathway in Tumor Progression
Current Cancer Drug Targets Synthesis and Anti Cervical Cancer Activity of Novel 5H-Thiochromeno [4,3-d]pyrimidines
Letters in Organic Chemistry