Current Concepts Underlying Benefits of Exercise Training in Congestive Heart Failure Patients

Author(s): Maqsood Elahi, Mohsin Mahmood, Ahmad Shahbaz, Naveed Malick, Jawad Sajid, Sanjay Asopa, Bashir M. Matata.

Journal Name: Current Cardiology Reviews

Volume 6 , Issue 2 , 2010

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Abstract:

The pathophysiology of several conditions including heart failure is partly attributable to a failure of the cell energy metabolism. Studies have shown that exercise training (ET) improves quality of life (QOL) and is beneficial in terms of reduction of symptoms, mortality and duration of hospitalization. Increasingly, ET is now achieving acceptance as complimentary therapy in addition to routine clinical practice in patients with chronic heart failure (CHF). However, the mechanisms underlying the beneficial effects of ET are far less understood and need further evaluation. Evidence suggests that while CHF induces generalized metabolic energy depletion, ET largely enhances the overall function of the heart muscle. Hence, research efforts are now aiming to uncover why ET is beneficial as a complimentary treatment of CHF in the context of improving endothelial function and coronary perfusion, decreasing peripheral resistance, induction of cardiac and skeletal muscle cells remodeling, increasing oxygen uptake, substrate oxidation, and resistance to fatigue. Here we discuss the current evidence that suggest that there are beneficial effects of ET on cardiac and skeletal muscle cells oxidative metabolism and intracellular energy transfer in patients with CHF.

Keywords: Heart failure, exercise training, proinflammatory cytokines, nitric oxide, myocardial function, ventilatory function, quality of life

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2010
Page: [104 - 111]
Pages: 8
DOI: 10.2174/157340310791162640
Price: $58

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