Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Anticancer Properties of Indole Compounds: Mechanism of Apoptosis Induction and Role in Chemotherapy

Author(s): Aamir Ahmad, Wael A Sakr, KM Wahidur Rahman.

Abstract:

Indole compounds, obtained from cruciferous vegetables, have been investigated for their putative anti-cancer properties. Studies with indole-3-carbinol (I3C) and its dimeric product, 3, 3-diindolylmethane (DIM), have indicated efficacy of these compounds against a number of human cancers. Available as well as emerging data suggests that these compounds act on a number of cellular signaling pathways leading to their observed biological effects. Such pleiotropic effects of these compounds are also considered crucial for their chemosensitization activity wherein they help reduce the toxicity and resistance against conventional chemotherapeutic drugs. These observations have major clinical implications especially in chemotherapy. Through this review, we have attempted to update current understanding on the state of anticancer research involving indole compounds. We have also summarized the available literature on modulatory effects of indoles on molecular targets such as survivin, uPA/uPAR and signaling pathways such as the NF-κB pathway, which are important for the apoptosis-inducing and chemosensitizing properties of these compounds.

Keywords: Indole-3-carbinol, Diindolylmethane, NF-κB, survivin, apoptosis, chemosensitization

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Article Details

VOLUME: 11
ISSUE: 6
Year: 2010
Page: [652 - 666]
Pages: 15
DOI: 10.2174/138945010791170923
Price: $58