Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Prenyloxyphenylpropanoids as a Novel Class of Anti-inflammatory Agents

Author(s): Salvatore Genovese, Massimo Curini, Francesco Epifano.

Abstract:

Oxyprenylated natural products (isopentenyloxy-, geranyloxy- and the less spread farnesyloxy- compounds and their biosynthetic derivatives) represent a family of secondary metabolites that have been considered for years just as biosynthetic intermediates of the most naturally widespread C-prenylated derivatives. Only in the last decade have these natural products been recognized as interesting and valuable biologically active phytochemicals. Up to now about 300 molecules were isolated from plants mainly belonging to the families of Rutaceae, Apiaceae, and Compositae, comprising common edible vegetables and fruits. A wide variety of compounds containing a prenyloxy side chain has been isolated and among these coumarins, cinnamic acids and aromatic ketones displayed the most efficient and promising biological activities as anti-inflammatory agents. The aim of this review is to examine in detail the anti-inflammatory properties of these novel class of natural products.

Keywords: Anti-inflammatory activity, prenyloxycoumarins, prenyloxycinnamic acids, rutaceae

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2010
Page: [158 - 165]
Pages: 8
DOI: 10.2174/187152310791110616
Price: $58