Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Mushrooms as a Source of Anti-Inflammatory Agents

Author(s): Ana Garcia-Lafuentea, Carlos Moro, Ana Villares, Eva Guillamon, Mauricio A. Rostagno, Matilde D'Arrigo, Jose Alfredo Martinez.

Abstract:

Inflammation is nowadays well known to be involved in the development of several chronic diseases such as arteriosclerosis, obesity, diabetes, neurodegenerative diseases, and cancer. Treatment for chronic inflammatory disorders has not been solved yet, and there is an urgent need to find new and safe anti-inflammatory preventive and therapeutic compounds. Medicinal mushrooms have been traditionally used in Asian countries to manage and treat different diseases. On the other hand, edible mushrooms have recently attracted much interest as a functional food because of their antimutagenic, anti-tumoral, anti-viral, anti-thrombotic, hypocholesterolemic, hypolipidemic, and anti-oxidant properties. Among all of these healthy properties, special attention was paid to the immunomodulatory activity of some fungal compounds such as polysaccharides, mainly β-glucans. Recently, some studies have demonstrated that both whole mushrooms and extracts may show anti-inflammatory activity due to the presence of bioactive compounds. This review summarizes the most recent studies investigating immunomodulatory and especially, anti-inflammatory properties of both medicinal and edible mushrooms, the compounds putatively implicated and the mechanisms that were already established.

Keywords: Mushrooms, immunomodulatory effect, anti-inflammatory effect, polysaccharides, antioxidants

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2010
Page: [125 - 141]
Pages: 17
DOI: 10.2174/187152310791110643
Price: $58