Abstract
Orexigenic peptides are group of endocrine hormones exerting a pleiotropic influence on many physiological functions including regulation of the feeding behaviour and energy expenditure, release of growth hormone (GH) and inotropic effects on the heart. Some of these peptides such as ghrelin, originally identified in the gastric mucosa, has been involved not only in control of food intake and growth hormone release but also exerts the immunomodulatory and anti-inflammatory properties. This review summarizes the recent attempts to prove the concept that orexigenic peptides such as ghrelin, orexin-A and obestatin besides playing an important role in the mechanism of food intake, exhibit a potent gastroprotective action against the formation of acute gastric mucosal injury induced by various ulcerogens. This protective effect depends upon vagal activity and hyperemia mediated by NOS/NO and COX/PG systems and CGRP released from sensory afferent nerves. In addition, the appetite peptides such as ghrelin and orexin-A are implicated in the mechanism of the healing of preexisting gastric ulcers due to an activation of specific GHS-R1a and OX-R1 receptors and PG/COX system.
Keywords: Ulcer healing, ghrelin, orexin-A, obestatin, prostaglandin, gastric blood flow, cyclooxygenase-1, cyclooxygenase-2
Current Pharmaceutical Design
Title: Involvement of Orexigenic Peptides in the Mechanism of Gastric Mucosal Integrity and Healing of Chronic Gastric Ulcers
Volume: 16 Issue: 10
Author(s): Aleksandra Szlachcic, Thomas Brzozowski, Jolanta Majka, Robert Pajdo, Peter. C. Konturek, Michal Pawlik, Slawomir Kwiecien, Danuta Drozdowicz, Wladyslaw Bielanski, Stanislaw J. Konturek and Wieslaw W. Pawlik
Affiliation:
Keywords: Ulcer healing, ghrelin, orexin-A, obestatin, prostaglandin, gastric blood flow, cyclooxygenase-1, cyclooxygenase-2
Abstract: Orexigenic peptides are group of endocrine hormones exerting a pleiotropic influence on many physiological functions including regulation of the feeding behaviour and energy expenditure, release of growth hormone (GH) and inotropic effects on the heart. Some of these peptides such as ghrelin, originally identified in the gastric mucosa, has been involved not only in control of food intake and growth hormone release but also exerts the immunomodulatory and anti-inflammatory properties. This review summarizes the recent attempts to prove the concept that orexigenic peptides such as ghrelin, orexin-A and obestatin besides playing an important role in the mechanism of food intake, exhibit a potent gastroprotective action against the formation of acute gastric mucosal injury induced by various ulcerogens. This protective effect depends upon vagal activity and hyperemia mediated by NOS/NO and COX/PG systems and CGRP released from sensory afferent nerves. In addition, the appetite peptides such as ghrelin and orexin-A are implicated in the mechanism of the healing of preexisting gastric ulcers due to an activation of specific GHS-R1a and OX-R1 receptors and PG/COX system.
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Szlachcic Aleksandra, Brzozowski Thomas, Majka Jolanta, Pajdo Robert, Konturek C. Peter., Pawlik Michal, Kwiecien Slawomir, Drozdowicz Danuta, Bielanski Wladyslaw, Konturek J. Stanislaw and Pawlik W. Wieslaw, Involvement of Orexigenic Peptides in the Mechanism of Gastric Mucosal Integrity and Healing of Chronic Gastric Ulcers, Current Pharmaceutical Design 2010; 16 (10) . https://dx.doi.org/10.2174/138161210790945940
DOI https://dx.doi.org/10.2174/138161210790945940 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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