Enhanced Fluorescence of Curcumin on Plasmonic Platforms

Author(s): Anindita Mukerjee , Rafal Luchowski , Amalendu P. Ranjan , Sangram Raut , Jamboor K. Vishwanatha , Zygmunt Gryczynski , Ignacy Gryczynski .

Journal Name: Current Pharmaceutical Biotechnology

Volume 11 , Issue 2 , 2010

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Abstract:

We report a significant increase of a curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) fluorescence brightness when deposited on plasmonic platforms (self assembled silver nanostructures formed on the surface of silver semitransparent film). The enhancement of fluorescence intensity is accompanied by a strong decrease in fluorescence lifetime. Simultaneously, the increased photostability of curcumin, a pigment showing strong antiinflammatory, antioxidant and antitumorigenic activity, allows long-time detection and monitoring. We believe that the use of plasmonic platforms will improve detection, delivery and imaging of curcumin.

Keywords: Fluorescence lifetime, metal enhanced fluorescence, photostability, plasmonic platforms, brightness, curcumin

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2010
Page: [223 - 228]
Pages: 6
DOI: 10.2174/138920110790909623
Price: $58

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