Current Pharmaceutical Biotechnology

Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth


Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?

Author(s): M. U. Sajjad, B. Samson and A. Wyttenbach

Affiliation: Southampton Neuroscience Group, School of Biological Sciences, University of Southampton, Boldrewood Campus, Basset Crescent East, Southampton SO16 7PX, UK.


Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (“proteinopathies”). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimers- and Parkinsons disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.

Keywords: Protein misfolding, neuroprotection, proteinopathies, molecular chaperones

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Article Details

Page: [198 - 215]
Pages: 18
DOI: 10.2174/138920110790909641
Price: $58