Current Pharmaceutical Biotechnology

Davide Prosperi
Department of Biotechnology and Bioscience
University of Milan Bicocca
Milano
Italy

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Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?

Author(s): M. U. Sajjad, B. Samson, A. Wyttenbach.

Abstract:

Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (“proteinopathies”). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimers- and Parkinsons disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.

Keywords: Protein misfolding, neuroprotection, proteinopathies, molecular chaperones

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2010
Page: [198 - 215]
Pages: 18
DOI: 10.2174/138920110790909641
Price: $58