Current Pharmaceutical Biotechnology

Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth


Cell-Penetrating Peptide Technology to Deliver Chaperones and Associated Factors in Diseases and Basic Research

Author(s): Gunnar P.H. Dietz

Affiliation: H. Lundbeck A/S, Dep. 828, Molecular Neurobiology, Ottiliavej 9, DK-2500 Valby, Denmark.

Keywords: Protein delivery, Trojan horse, HIV-Tat, Antennapedia (Penetratin), arginine-rich peptide, Ischemia, stroke, Pep-1


Cell-penetrating peptides (CPP), also called protein transduction domains (PTD), membrane-permeable peptides (MPP), or Trojan horse peptides, have been used in many different research areas. The delivery of heat shock proteins (Hsp) using CPP has been applied in models for apoptosis, necrosis, oxidative stress, neurodegenerative diseases, stroke, cystic fibrosis, smooth muscle relaxation, myocardial injury, scar formation, and others. This review summarizes the accomplishments of the field over the last years and discusses why Hsp are particularly suitable for CPP-mediated delivery.

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Article Details

Page: [167 - 174]
Pages: 8
DOI: 10.2174/138920110790909731