The Role of PEDF in Tumor Growth and Metastasis

Author(s): D. Hoshina, R. Abe, S.-I. Yamagishi, H. Shimizu.

Journal Name: Current Molecular Medicine

Volume 10 , Issue 3 , 2010

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Abstract:

Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.

Keywords: PEDF, tumor, growth, metastasis

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2010
Page: [292 - 295]
Pages: 4
DOI: 10.2174/156652410791065327
Price: $58

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