Development of an Artificial Chaperone System Based on Cyclodextrin

Author(s): Yoshihiro Sasaki, Kazunari Akiyoshi.

Journal Name: Current Pharmaceutical Biotechnology

Volume 11 , Issue 3 , 2010

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Abstract:

Molecular chaperones in living systems inspired us to explore new concepts for assisting protein refolding. The chaperone selectively interacts with a non-native protein by hydrophobic interaction to prevent irreversible aggregation and releases the protein in its refolded form with the aid of ATP and another co-chaperone. Cyclodextrins have been used to simulate the function of the chaperones by controlling the hydrophobic interaction with proteins. In this chapter, we review the cyclodextrin (CD)-related protein refolding systems.

Keywords: Cyclodextrin, artificial chaperone, surfactant, nanogel, hydrophobized polymer

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2010
Page: [300 - 305]
Pages: 6
DOI: 10.2174/138920110791111951
Price: $58

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