Abstract
Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.
Keywords: Liver-directed therapy, regional therapy, hepatocellular cancer, chemoembolization, radioembolization
Current Cancer Therapy Reviews
Title: Liver-Directed Regional Therapy in the Multi-Disciplinary Management of Hepatocellular Cancer
Volume: 6 Issue: 1
Author(s): Maheswari Senthil, Brian Mailey, Lucille Leong, Vincent Chung, Yun Yen, Yi-Jen Chen, Howard Marx and Joseph Kim
Affiliation:
Keywords: Liver-directed therapy, regional therapy, hepatocellular cancer, chemoembolization, radioembolization
Abstract: Hepatocellular carcinoma (HCC) is a major worldwide health concern with an increasing incidence in the United States. Orthotopic liver transplantation (OLT) has been established as the gold standard for curative therapy of HCC. Because of limited organ supply and socioeconomic factors, OLT is often not a viable option. Surgical resection and ablation are also effective for providing long-term survival. However, most patients are ineligible for curative surgical therapy due to advanced disease. For these patients, effective treatment options have been lacking. Systemic chemotherapy and even recent biologic, targeted agents have shown little to minimal efficacy. Liver-directed regional therapies, including trans-arterial chemoembolization (TACE) and selective internal radiation treatment (SIRT) with Yttrium-90 radioembolization have emerged in recent years as effective therapies to provide local control of disease. Randomized trials have demonstrated a survival benefit for TACE, and SIRT has shown efficacy as an embolic alternative to TACE. Here we review the experience of liver-directed regional therapies and provide a clear rationale for their implementation in a multi-disciplinary algorithmic approach to the management of HCC.
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Senthil Maheswari, Mailey Brian, Leong Lucille, Chung Vincent, Yen Yun, Chen Yi-Jen, Marx Howard and Kim Joseph, Liver-Directed Regional Therapy in the Multi-Disciplinary Management of Hepatocellular Cancer, Current Cancer Therapy Reviews 2010; 6 (1) . https://dx.doi.org/10.2174/157339410790596461
DOI https://dx.doi.org/10.2174/157339410790596461 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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