Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes

Author(s): Luca Ronconi, Donatella Aldinucci, Q. Ping Dou, Dolores Fregona.

Abstract:

In this review paper we aim at giving a detailed overview on our research work devoted to the design of gold-based anticancer agents. In particular, during the last decade, we have been developing some gold(III)-dithiocarbamato derivates showing outstanding in vitro and in vivo antitumor properties and reduced, or even no, systemic and renal toxicity, compared to the reference clinically-established anticancer drug cisplatin. Starting from the rationale behind our investigations, we here summarize the results achieved so far, focusing on the latest in-depth mechanistic studies that have recently provided insights into their mechanism of action, thus opening up new prospects for further pharmacological testing and, hopefully, to enter clinical trials.

Keywords: Anticancer drug, Dithiocarbamate, Gold compounds, Metallodrug, Nephrotoxicity, Proteasome inhibitor, Reactive oxygen species (ROS), Thioredoxin reductase (TrxR)

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Article Details

VOLUME: 10
ISSUE: 4
Page: [283 - 292]
Pages: 10
DOI: 10.2174/187152010791162298
Price: $58