Larry C. Wienkers is currently the Executive Director for the Department of Pharmacokinetics and Drug Metabolism at Amgen in Seattle, WA. Larrys areas of scientific interest include: understanding of the mechanisms of cytochrome P450 oxidation reactions; the application of novel in vitro metabolism techniques to understand the enzymatic basis for biotransformation of potential therapeutic agents at the drug discovery interface; and the prospective application of in vitro metabolism data to predict clinically relevant pharmacokinetically based drug-drug interactions. Larry holds a BSc. and MS. in Chemistry from Western Washington University (1986 & 1988) and Ph.D. in Medicinal Chemistry from the University of Washington (1993). Larry worked as a Postdoctoral Fellow, in the Department of Drug Metabolism at the Upjohn Company (1993-1995) and he joined Pharmacia and Upjohn as a Research Scientist (1995). Larry became Director of Drug Metabolism Enabling Technologies and Scientific Fellow at Pharmacia, Kalamazoo MI (1998). In 2003, Larry became Executive Director in the Department of Pharmacokinetics, Dynamics and Metabolism at Pfizer St Louis, MO. Larry has co-authored more than 50 peer reviewed manuscripts, 4 book chapters and currently holds 1 patent. He is co-Editor of the Handbook of Drug Metabolism, and is a member of the Editorial Board for the journals: Drug Metabolism and Disposition, Open Medicinal Chemistry Letters, and Current Drug Metabolism.