Current Bioactive Compounds

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100
Italy

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Cholinesterase Interactions with Oximes

Author(s): Z. Kovarik, M. Katalinic, A. Bosak, G. Sinko.

Abstract:

The phosphorylation of the serine hydroxyl group in the active site of acetylcholinesterase (AChE) inactivates this essential enzyme in neurotransmission. Oximes are reactivators of AChE phosphorylated by organophosphorus compounds (OP) including insecticides and nerve agents. The effectiveness of oxime-assisted reactivation is primarily attributed to the nucleophilic displacement rate of organophosphate, but efficiency varies with the structure of the bound

Keywords: Acetylcholinesterase, antidote, bioscavenger, butyrylcholinesterase, nerve agents, tabun, oxime, treatment

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2010
Page: [9 - 15]
Pages: 7
DOI: 10.2174/157340710790711764