Stereoselective Metabolic and Pharmacokinetic Analysis of the Chiral Active Components from Herbal Medicines

Title: Stereoselective Metabolic and Pharmacokinetic Analysis of the Chiral Active Components from Herbal Medicines

Volume: 6 Issue: 1

Author(s): Xiaowen Wang and Su Zeng

Affiliation:

Keywords: Chiral analysis, Drug metabolism, Pharmacokinetics, Herbal medicines

Abstract: The discrimination and evaluation of stereoselective metabolism of enantiomers are of paramount significance for developing effective and safe chiral drugs. However, there is still a lack of comprehensive and in-depth understanding of stereospecific disposition of chiral components in Herbal Medicines. In this article, stereoselective methods including capillary electrophoresis, high-performance liquid chromatography, gas chromatography, supercritical fluid chromatography and hyphenation techniques for chiral drug metabolism studies are reviewed. Furthermore, applications of modern analytical techniques to study enantioselective metabolic profiling of the active components from Herbal Medicines in vitro and in vivo in recent years are also presented and the representative examples are enumerated.

Cite this article as:

Wang Xiaowen and Zeng Su, Stereoselective Metabolic and Pharmacokinetic Analysis of the Chiral Active Components from Herbal Medicines, Current Pharmaceutical Analysis 2010; 6 (1) . https://dx.doi.org/10.2174/157341210790780221