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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

“How to Manage Loss of Response to Anti-TNF in Crohns Disease?”

Author(s): Walter Reinisch

Volume 11, Issue 2, 2010

Page: [152 - 155] Pages: 4

DOI: 10.2174/138945010790309894

Price: $65

Abstract

Despite the fact that anti-TNF alpha antibodies are well-tolerated and highly effective in Crohns disease 25% to 40% of patients who initially benefited from the treatment are developing intolerable adverse events or are losing their response during maintenance therapy. The molecular mechanisms of loss of response are not fully understood, but clinicians face this clinical problem. The Aim of this paper is to review the clinical strategies to face loss of response to anti- TNF alpha antibodies in Crohns disease.


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