Brevibacillus Expression System: Host-Vector System for Efficient Production of Secretory Proteins

Author(s): Makoto Mizukami, Hiroshi Hanagata, Akira Miyauchi.

Journal Name: Current Pharmaceutical Biotechnology

Volume 11 , Issue 3 , 2010

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Abstract:

Brevibacillus expression system is an effective bacterial expression system for secretory proteins. The host bacterium, Brevibacillus choshinensis, a gram-positive bacterium, has strong capacity to secrete a large amount of proteins (∼30g/L), which mostly consist of cell wall protein. A host-vector system that utilizes such high expression capacity has been constructed for the production of secretory proteins and tested for various heterologous proteins, including cytokines, enzymes, antigens, and adjuvants.

Keywords: Brevibacillus choshinensis, host-vector system, secretory production, recombinant protein, gram-positive bacteria

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2010
Page: [251 - 258]
Pages: 8
DOI: 10.2174/138920110791112031
Price: $58

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