Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE
USA

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Structure-Function Relationships of PEDF

Author(s): T. Kawaguchi, S.-I. Yamagishi and M. Sata

Affiliation: Department of Digestive Disease Information&Research, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.

Keywords: Pigment epithelial-derived factor, functional domain, anti-angiogenic activity, anti-vasopermeability activity, anti-tumor activity, neurotrophic activity, glucose metabolism, lipid metabolism

Abstract:

Pigment epithelial-derived factor (PEDF) is a 50-kDa secreted glycoprotein that belongs to the non-inhibitory serpin. It has an α/β core serine-protease inhibitor domain, 3 major β-sheets, and 10 α-helices. Although PEDF does not inhibit either serine or cysteine proteinases, PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. Recent studies have shown that a variety of peptides derived from PEDF possess activities similar to those of the parent molecule through interactions with the extracellular matrix, binding to PEDF receptors, nuclear localization and phosphorylation. Thus, peptides derived from PEDF have therapeutic potential for various diseases and therefore, it is important to clarify the structure-function relationship of PEDF. In this review, we summarize structural features of PEDF that could affect various target organs such as blood vessels, tumors, and the central nervous system. In addition, since PEDF is recently identified as a regulator for glucose and lipid metabolism, we also discuss PEDF structures specially related to insulin-sensitizing and triglyceride-reducing properties.

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Article Details

VOLUME: 10
ISSUE: 3
Page: [302 - 311]
Pages: 10
DOI: 10.2174/156652410791065255