Abstract
The immune system is the responsible for body integrity and the prevention of external invasion. In principle, the immune system has not been evolutionarily trained to respond against inorganic engineered nanoparticles (NPs). However, how it will react against them will determine developments on the use of NPs as medical devices and their toxicological impact on human and environmental health. Initial observations show a broad range of results as a function of size, shape, concentration and surface state of NPs, and a variety of immune responses from absent to acute inflammation. In particular for the case of NP, the composition of the material, which strongly influences its physical properties, appears not to be the main determining factor for their behavior in biological environments as compared to surface state or size.
Keywords: Nanoparticles, nanomaterials, surface modification, immune system, macrophages, endocytosis, inflammation, biodegradation
Current Drug Metabolism
Title: Inorganic Engineered Nanoparticles and Their Impact on the Immune Response
Volume: 10 Issue: 8
Author(s): Ralph A. Sperling, Eudald Casals, Joan Comenge, Neus G. Bastus and Victor F. Puntes
Affiliation:
Keywords: Nanoparticles, nanomaterials, surface modification, immune system, macrophages, endocytosis, inflammation, biodegradation
Abstract: The immune system is the responsible for body integrity and the prevention of external invasion. In principle, the immune system has not been evolutionarily trained to respond against inorganic engineered nanoparticles (NPs). However, how it will react against them will determine developments on the use of NPs as medical devices and their toxicological impact on human and environmental health. Initial observations show a broad range of results as a function of size, shape, concentration and surface state of NPs, and a variety of immune responses from absent to acute inflammation. In particular for the case of NP, the composition of the material, which strongly influences its physical properties, appears not to be the main determining factor for their behavior in biological environments as compared to surface state or size.
Export Options
About this article
Cite this article as:
Sperling A. Ralph, Casals Eudald, Comenge Joan, Bastus G. Neus and Puntes F. Victor, Inorganic Engineered Nanoparticles and Their Impact on the Immune Response, Current Drug Metabolism 2009; 10 (8) . https://dx.doi.org/10.2174/138920009790274577
DOI https://dx.doi.org/10.2174/138920009790274577 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Tissue Distribution and Metabolism of Micro- and Nanoparticles and Medical Implants
With the continuous advancement of modern science and engineering, numerous functional materials and active molecules have been developed and utilized in various industrial, medical, and food applications. Many of these can enter the body, either actively or passively, and have significant and intricate impacts on human health. For example, biomaterials ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Membrane Estrogen Receptors Acting in the Central Nervous System
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Determination of Spatial and Temporal Distribution of Microglia by 230nm-High-Resolution, High-Throughput Automated Analysis Reveals Different Amyloid Plaque Populations in an APP/PS1 Mouse Model of Alzheimers Disease
Current Alzheimer Research Liposomal-All-trans-Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Current Cancer Therapy Reviews Mechanisms of Inhibitory and Regulatory Effects of Methylenedioxyphenyl Compounds on Cytochrome P450-Dependent Drug Oxidation
Current Drug Metabolism Current and Future Drug Treatments for Glioblastomas
Current Medicinal Chemistry Pomegranate Extract, A Prooxidant with Antiproliferative and Proapoptotic Activities Preferentially Towards Carcinoma Cells
Anti-Cancer Agents in Medicinal Chemistry Signaling Through Rho GTPase Pathway as Viable Drug Target
Current Medicinal Chemistry Exogenous Progesterone: A Potential Therapeutic Candidate in CNS Injury and Neurodegeneration
Current Medicinal Chemistry Functional Roles of Synaptic and Extrasynaptic NMDA Receptors in Physiological and Pathological Neuronal Activities
Current Drug Targets Peptidyl Arginine Deiminases and Neurodegenerative Diseases
Current Medicinal Chemistry Restless Legs Syndrome in Children: A Review and Update on Pharmacological Options
Current Pharmaceutical Design Inhibition of Transcription Factors by Plant-Derived Compounds and their Implications in Inflammation and Cancer
Current Pharmaceutical Design Biological Activities of the Essential Oil of Zanthoxylum armatum DC. Leaves
The Natural Products Journal Acute Symptomatic Seizures in Geriatric Patients with Multiple Risk Factors - A Diagnostic Challenge
Current Aging Science Adrenomedullin and Oxidative Stress in Vascular Damage and Metabolic Disease
Current Hypertension Reviews Editorial [Hot topic: Role of Inflammation in Neurological and Psychiatric Disorders (Guest Editor: Mohtashem Samsam)]
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Effects of N-Acetyl-L-Cysteine and Hyaluronic Acid on HBOC-201- Induced Systemic and Cerebral Vasoconstriction in the Rat
Current Drug Discovery Technologies Cannabinoid Receptor Type 2 Activation in Atherosclerosis and Acute Cardiovascular Diseases
Current Medicinal Chemistry Molecular and Biochemical Changes of the Cardiovascular System due to Smoking Exposure
Current Pharmaceutical Design Neuronal Nicotinic Receptors and Neuroprotection: Newer Ligands May Help us Understand their Role in Neurodegeneration
Medicinal Chemistry Reviews - Online (Discontinued)