Multicomponent Synthesis of Cyclic Frameworks on Knoevenagel-Initiated Domino Reactions

Author(s): Yi-Feng Han, Min Xia.

Journal Name: Current Organic Chemistry

Volume 14 , Issue 4 , 2010

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Major aspects of multicomponent synthesis of cyclic frameworks are reviewed with special focus on Knoevenagel-based domino reactions. Particularly, the Knoevenagel-Cycloaddition and the Knoevenagel-Michael cascades are the majority of reaction types which contribute to the building of complicated cyclic molecular scaffolds. Although samples of the other Knoevenagel-induced reactions are not abundant, their creativity in production of novel cyclic structures should not be neglected. The presented reports herein are sufficient enough to confirm that Knoevenagel-induced domino reactions have been one of the most powerful and productive tools for the construction of novel and complicated frameworks.

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Article Details

Year: 2010
Page: [379 - 413]
Pages: 35
DOI: 10.2174/138527210790231865
Price: $58

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