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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Multicomponent Synthesis of Cyclic Frameworks on Knoevenagel-Initiated Domino Reactions

Author(s): Yi-Feng Han and Min Xia

Volume 14, Issue 4, 2010

Page: [379 - 413] Pages: 35

DOI: 10.2174/138527210790231865

Price: $65

Abstract

Major aspects of multicomponent synthesis of cyclic frameworks are reviewed with special focus on Knoevenagel-based domino reactions. Particularly, the Knoevenagel-Cycloaddition and the Knoevenagel-Michael cascades are the majority of reaction types which contribute to the building of complicated cyclic molecular scaffolds. Although samples of the other Knoevenagel-induced reactions are not abundant, their creativity in production of novel cyclic structures should not be neglected. The presented reports herein are sufficient enough to confirm that Knoevenagel-induced domino reactions have been one of the most powerful and productive tools for the construction of novel and complicated frameworks.


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