Mechanistic Variations of the Povarov Multicomponent Reaction and Related Processes

Author(s): Davide Bello, Rosario Ramon, Rodolfo Lavilla.

Journal Name: Current Organic Chemistry

Volume 14 , Issue 4 , 2010

Become EABM
Become Reviewer


The Povarov reaction is a multicomponent process involving anilines, carbonyl compounds and activated olefins to afford tetrahydroquinolines. The mechanism of this domino reaction comprises a sequence of steps linking imine formation, a Mannich-type reaction and an intramolecular aromatic electrophilic substitution. Here we analyze the scope of the methodology, with a particular emphasis on mechanistic variations, new synthetic inputs, reaction modes, structural diversity originated from this process and its applications to organic chemistry.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2010
Page: [332 - 356]
Pages: 25
DOI: 10.2174/138527210790231883
Price: $58

Article Metrics

PDF: 23