Mechanistic Variations of the Povarov Multicomponent Reaction and Related Processes

Author(s): Davide Bello , Rosario Ramon , Rodolfo Lavilla .

Journal Name: Current Organic Chemistry

Volume 14 , Issue 4 , 2010

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Abstract:

The Povarov reaction is a multicomponent process involving anilines, carbonyl compounds and activated olefins to afford tetrahydroquinolines. The mechanism of this domino reaction comprises a sequence of steps linking imine formation, a Mannich-type reaction and an intramolecular aromatic electrophilic substitution. Here we analyze the scope of the methodology, with a particular emphasis on mechanistic variations, new synthetic inputs, reaction modes, structural diversity originated from this process and its applications to organic chemistry.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2010
Page: [332 - 356]
Pages: 25
DOI: 10.2174/138527210790231883
Price: $58

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