Abstract
The Povarov reaction is a multicomponent process involving anilines, carbonyl compounds and activated olefins to afford tetrahydroquinolines. The mechanism of this domino reaction comprises a sequence of steps linking imine formation, a Mannich-type reaction and an intramolecular aromatic electrophilic substitution. Here we analyze the scope of the methodology, with a particular emphasis on mechanistic variations, new synthetic inputs, reaction modes, structural diversity originated from this process and its applications to organic chemistry.
Current Organic Chemistry
Title: Mechanistic Variations of the Povarov Multicomponent Reaction and Related Processes
Volume: 14 Issue: 4
Author(s): Davide Bello, Rosario Ramon and Rodolfo Lavilla
Affiliation:
Abstract: The Povarov reaction is a multicomponent process involving anilines, carbonyl compounds and activated olefins to afford tetrahydroquinolines. The mechanism of this domino reaction comprises a sequence of steps linking imine formation, a Mannich-type reaction and an intramolecular aromatic electrophilic substitution. Here we analyze the scope of the methodology, with a particular emphasis on mechanistic variations, new synthetic inputs, reaction modes, structural diversity originated from this process and its applications to organic chemistry.
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Cite this article as:
Bello Davide, Ramon Rosario and Lavilla Rodolfo, Mechanistic Variations of the Povarov Multicomponent Reaction and Related Processes, Current Organic Chemistry 2010; 14 (4) . https://dx.doi.org/10.2174/138527210790231883
DOI https://dx.doi.org/10.2174/138527210790231883 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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