Recent Advances in Ligand Design for the Intermolecular Asymmetric Mizoroki- Heck Reaction

Author(s): Vincent Coeffard, Patrick J. Guiry.

Journal Name: Current Organic Chemistry

Volume 14 , Issue 3 , 2010

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Abstract:

This review deals with recent advances in ligand design for the intermolecular asymmetric Mizoroki-Heck reaction. Since the seminal report by Hayashi and co-workers in 1991 on the intermolecular asymmetric Mizoroki-Heck reaction, research on new and improved catalytic systems has become a field of growing interest. Over the last decade, efforts have been made to develop stable and easily synthesised ligands that induce high reactivity and selectivity (regio- and enantioselectivity) with a wide range of substrates. This review covers important developments in this field over the last decade by focusing on ligand design and applications. The article is organised according to the ligand class: [P,P], [P,N] and other ligand classes involved in the intermolecular asymmetric Mizoroki-Heck reaction.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2010
Page: [212 - 229]
Pages: 18
DOI: 10.2174/138527210790231928
Price: $58

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