Can Microbicides Turn the Tide Against HIV?

Author(s): Koreen Ramessar, Maite Sabalza, Bruna Miralpeix, Teresa Capell, Paul Christou.

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 4 , 2010

Abstract:

The global impact of human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) is increasing and traditional preventative ‘safe sex’ strategies do not seem to be slowing the spread of this virus. With an efficacious vaccine at least a decade away, the only strategy to avoid the ever-increasing cost of highly active antiretroviral therapy (HAART) is to develop new methods that prevent virus transmission. Microbicides are topicallyapplied molecules that disrupt the HIV cycle and block infection. This review discusses the current state of the art in microbicide development, looking at the most clinically advanced microbicides and those at earlier development stages based on their mechanisms of action. The socioeconomic impact of microbicide use is also considered, as this will determine whether microbicides are taken up and used consistently by the target population.

Keywords: Microbicide, HIV/AIDS, surfactant, antiretroviral, combination microbicide, umbrella compound, developing country, socioeconomic impact

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Article Details

VOLUME: 16
ISSUE: 4
Year: 2010
Page: [468 - 485]
Pages: 18
DOI: 10.2174/138161210790232202
Price: $58

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