Current Genomics

Christian Néri
Institute of Biology Paris-Seine
CNRS UMR 8256 and UPMC
Paris, 75005
France

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Simulation of Genes and Genomes Forward in Time

Author(s): Antonio Carvajal-Rodriguez

Affiliation: Departamento de Bioquimica, Genetica e Inmunologia, Universidad de Vigo, 36310 Vigo, Spain.

Abstract:

The importance of simulation software in current and future evolutionary and genomic studies is just confirmed by the recent publication of several new simulation tools. The forward-in-time simulation strategy has, therefore, re-emerged as a complement of coalescent simulation. Additionally, more efficient coalescent algorithms, the same as new ideas about the combined use of backward and forward strategies have recently appeared. In the present work, a previous review is updated to include some new forward simulation tools. When simulating at the genome-scale the conflict between efficiency (i.e. execution speed and memory usage) and flexibility (i.e. complex modeling capabilities) emerges. This is the pivot around which simulation of evolutionary processes should improve. In addition, some effort should be made to consider the process of developing simulation tools from the point of view of the software engineering theory. Finally, some new ideas and technologies as general purpose graphic processing units are commented.

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Article Details

VOLUME: 11
ISSUE: 1
Page: [58 - 61]
Pages: 4
DOI: 10.2174/138920210790218007